HU-210 is a potent analgesic with many of the same effects as natural THC.

It is a highly potent analgesic drug several thousand times stronger than morphine, with a similar "in vivo" potency to etorphine.

Another ancient analgesic method, aging back to 5000 BCE in Sumer, is to use natural minerals, vitamins, and herbs, usually in a mixture with other natural products.

Acupoint stimulation is as effective as dermatomal stimulation in producing an analgesic-sparing effect after lower abdominal surgery H-wave therapy.

In a 1999 randomized controlled trial involving a mechanical pain model, the analgesic effects of HWT were found to be short-lasting and identical to those provided by TENS therapy.

With ICT, its postulated mechanism of analgesic action is through direct stimulation of muscle fibers rather than nerves, allegedly improving muscle blood flow and promoting the healing process.

Piezo-electric current therapy, or PECT, is an analgesic technique based on the principle that mechanical deformation of a motorized piezoelectric ceramic rod produces a burst of 10 electrical pulses (five positive and five negative), each lasting 2–3 ms.

Properidine is an opioid analgesic and the isopropyl analog of pethidine.

In the case of laser surgery, a narcotic analgesic is typically used.

The painkillers he has been prescribed are ineffective, and his use of alcohol as an analgesic has led to his alcoholism.

The syndrome included "…severe, persistent, paroxysmal, often intolerable, pains on the hemiplegic side, not yielding to any analgesic treatment".

Methoxyflurane has been extensively used since the 1970s in Australia as an emergency analgesic for short-term use, mostly by the Australian and New Zealand Defence Forces, and the Australian ambulance services.

The Analgizer inhaler was withdrawn in 1974, but use of methoxyflurane as a sedative and analgesic continues in Australia and New Zealand in the form of the Penthrox inhaler.

It has neuroprotective, analgesic, and anti-Parkinsonian effects in animal studies.

At that time, he proposed that the mechanism of the analgesic action of nonsteroidal antiinflammatory drugs (NSAID) was due to the prevention of pain receptor sensitization which results from an inhibition of the synthesis of prostaglandins.

Experiments examining pain regulatory systems have shown that fibromyalgia patients display an exaggerated wind-up in response to repetitive stimulation and an absence of exercise-induced analgesic response.

Considering drugs such as loperamide, which acted on the opioid receptors in the gut without acting on the central nervous system, Goldberg proposed a targeted opioid receptor antagonist. Thousands of opioid-like molecules had been synthesized by pharmaceutical companies looking for the better analgesic - and many of those with no pain relieving properties had been shelved.

Cannabinoids can serve as appetite stimulants, antiemetics, antispasmodics, and have some analgesic effects, may be helpful treating chronic non-cancerous pain, or vomiting and nausea caused by chemotherapy.

In the medieval Islamic world, Arabic physicians made use of the diuretic, antiemetic, antiepileptic, anti-inflammatory, analgesic and antipyretic properties of "Cannabis sativa", and used it extensively as medication from the 8th to 18th centuries.

Laboratory experiments have shown that cannabinoids found in marijuana may have analgesic and anti-inflammatory effects.