Definition: V-shaped cut in a surface; V.
Definition: V-shaped cut in a surface; V.
Sentences Containing 'notch'
Evacuation was ordered for 26 households in the Pine Needle Notch mountain subdivision.
The Hop River's marshy source is just southeast of Bolton Notch, Connecticut.
The Sterno-mastoids, when marked, are indicated by grooves running to the sternal notch.
Median line is sometimes marked by a groove from sternal notch to navel.
Although a notch filter to suppress the intermodulation products is used at the output of the intercarrier transmitter, the cost of the notch filter is not comparable to the cost of extra amplifiers and the output combiner.
Intermodulation products and notch filters.
That is why notch filters are used in intercarrier system.
He also helped New Hampshire acquire Franconia Notch and Crawford Notch as public lands, and established a river conservation group in Quebec.
The following season wasn't as prolific, with Hinds managing to notch up only four goals in 26 appearances.
He was involved in a back and forth over Twitter with Notch of Minecraft fame.[http://i.imgur.com/bVvND.png] Education.
Notch is present in all metazoans, and mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4.
The notch receptor is a single-pass transmembrane receptor protein.
The Notch protein spans the cell membrane, with part of it inside and part outside.
The Notch binding allows groups of cells to organize themselves, such that, if one cell expresses a given trait, this may be switched off in neighbouring cells by the intercellular notch signal. In this way, groups of cells influence one another to make large structures.
Thus, lateral inhibition mechanisms are key to Notch signaling.
The notch cascade consists of notch and notch ligands, as well as intracellular proteins transmitting the notch signal to the cell's nucleus.
Notch and most of its ligands are transmembrane proteins, so the cells expressing the ligands typically must be adjacent to the notch expressing cell for signaling to occur.
Notch 1, for example, has 36 of these repeats.
The addition of "O"-fucose by POFUT1 is absolutely necessary for notch function, and, without the enzyme to add "O"-fucose, all notch proteins fail to function properly.
As yet, the manner by which the glycosylation of notch affects function is not completely understood.
These enzymes are responsible for something called a "fringe effect" on notch signaling.
Once the notch extracellular domain interacts with a ligand, an ADAM-family metalloprotease called TACE (Tumor Necrosis Factor Alpha Converting Enzyme), cleaves the notch protein just outside the membrane.
This releases the extracellular portion of notch, which continues to interact with the ligand.
The ligand plus the notch extracellular domain is then endocytosed by the ligand-expressing cell.
It was originally thought that these CSL proteins suppressed Notch target transcription.
Other proteins also participate in the intracellular portion of the notch signaling cascade.
Notch signaling is required in the regulation of polarity.
Also, Notch signaling is required during left-right asymmetry determination in vertebrates.
Notch signaling is central to somitogenesis.
Further studies identified the role of Notch signaling in the segmentation clock.
Notch signaling in central nervous system development and function.
Notch signaling in neuron cell differentiation.
The Notch pathway is essential for maintaining NPCs in the developing brain.
Modulators of the Notch signal, e.g., the Numb protein are able to antagonize Notch effects, resulting in the halting of cell cycle and differentiation of NPCs.
"In vitro" studies show that Notch can influence neurite development.
Notch signaling in adult brain function.
Similar results are seen in experiments with presenilins1 and 2, which mediate the Notch intramembranous cleavage.
Notch signaling in cardiovascular development.
The Notch signaling pathway is a critical component of cardiovascular formation and morphogenesis in both development and disease.
Notch signaling may be used to control the sprouting pattern of blood vessels during angiogenesis.
Notch signaling in endocrine development.
Many studies have indicated that Notch signaling has a major role in endocrine development.
Notch signaling in pancreatic development.
The expression of elements of the Notch signaling pathway have been found in the developing pancreas, suggesting that Notch signaling is important in pancreatic development.
A second mechanism is "suppressive maintenance", which explains the role of Notch signaling in pancreas differentiation.
Notch signaling and intestinal development.
The role of Notch signaling in the regulation of gut development has been indicated in several reports.
Overexpression of Notch signaling inhibits bone morphogenetic protein2-induced osteoblast differentiation.
A key notch—located differently in DDR2 and DDR3 DIMMs—prevents accidentally interchanging them.
Not surprisingly, they are also priced a notch higher than other frame makers.
More Vocab Words::: mandatory - obligatory; compulsory; of a mandate
::: feasible - practical; able to be carried out; practicable
::: tether - tie (an animal) with a rope or tether; N: rope or chain to which an animal is tied; limit of one's endurance; Ex. the end of one's tether
::: fluency - smoothness of speech; ADJ. fluent
::: fluted - having vertical parallel grooves (as in a pillar); V. flute: make long parallel inward curves in; N. flute: long rounded groove incised on the shaft of a column
::: rhetoric - art of effective communication; art of using language effectively and persuasively; style of speaking or writing; grandiloquent language; Ex. political rhetoric; ADJ. rhetorical; CF. rhetorical question: question to which no answer is expected as ``Who knows it ?''
::: douse - plunge into water or liquid; dip; immerse; drench; wet throughly; extinguish; throw water over; dowse
::: lucid - easily understood; clear; intelligible; N. lucidity
::: mammoth - gigantic; enormous
::: collateral - security given for loan; ADJ: secondary; descended from the same person but through different sons or daughters